ESPE Yearbook of Paediatric Endocrinology

Heart. 2020 Nov 23:heartjnl-2020-317802. doi: 10.1136/heartjnl-2020-317802. PMID: 33234670.In brief: This parallel-arm trial randomly assigned 294 adults with abdominal obesity/dyslipidemia to 1 of 3 dietary guidelines: healthy diet; Mediterranean diet; or ‘green Mediterranean’ diet. All groups received physical activity guidelines. Weight loss was higher in the two...

Brief summary: This randomized, multicenter, controlled, phase II study compared the effects of high-dose (HD) once-weekly PEGylated-recombinant human growth hormone (PEG-rhGH) to low-dose (LD) and to an untreated control group of children with idiopathic short stature (ISS) over a period of 52 weeks. PEG-rhGH was effective in increasing height gain in a dose dependent manner with both doses being well tolerated during the observation period.PEG-rhGH is ...

Brief Summary: The management of phaeochromocytomas and paragangliomas in patients with pathogenic variants of succinate dehydrogenase complex iron sulfur subunit B ( SDHD ) gene is complex. An international group of experts performed a critical review of the evidence to produce this consensus statement to assist clinical decision-making.Comment: Pathogenic variants in succinate dehydrogenase complex iron sulfur subunit B ( SDHD ) gene ...

Abstract: Nat Med. 2019 Apr;25(4):583–590. PMID: 30804514In brief: This study describes the first skeletal dysplasia caused by a mutation in a microRNA that is not simply inactivating, but modifies the repertoire of target genes.Comment: MicroRNAs (miRNAs) are small (20–24 nucleotides) noncoding RNA molecules that post-transcriptio...

Brief summary: This longitudinal observational multicentre retrospective study, collected data on 95 young prepubertal or early pubertal girls (age >10.9 years, Tanner stage ≤2) with premature ovarian failure (POI) or hypogonadotropic hypogonadism (HH). Their hypogonadism was due to different causes and was treated with transdermal 17β-oestradiol, with a follow-up of at least 1 year. The study aimed to identify the most physiological and effective therapeutic sc...

J Cancer Surviv. 2021; 15: 259–272. https://pubmed.ncbi.nlm.nih.gov/32844376/Long-term treatment effects are possible reasons for reduced fertility and adverse pregnancy outcomes in childhood cancer survivors (CCS) (1). This observational study reports perinatal and health outcomes of offspring born to CCS using assisted reproductive technologies (ART). CCS were almost 2-fold more like...

Arch Dis Child Fetal Neonatal Ed. 2022 Mar 14:fetalneonatal-2021-323296. doi: 10.1136/archdischild-2021-323296. Epub ahead of print. PMID: 35288450.Brief Summary: This study tested the hypothesis that the diurnal cortisol area under the curve (mean daily level) and diurnal cortisol slope (decline across the day) differ between infants born preterm and those born at term. Extremely pr...

t.palmer@ucl.ac.uk Pediatr Diabetes 2022; 23:19–32. doi: 10.1111/pedi.13277Brief Summary: The Changing Diabetes in Children (CDiC) program successfully established a stable supply of free insulin in implementing facilities for children living in Kenya and Bangladesh. However, the program also has limitations, including concerns over its sustainability.<...

To read the full abstract: J Pediatr Endocrinol Metab. 2017;30:869-877Several previous studies had focused on the early risk of metabolic syndrome or its components in survivors of childhood acute lymphoblastic leukaemia (ALL), while fewer data are available on pubertal development in these subjects. The merit of this study was to carefully investigate growth and pubertal development in a large ...

To read the full abstract: Diabetes Care. 2018;41:128-135Renal damage and kidney failure are amongst the most detrimental co-morbidities of T1DM. In order to be able to prevent renal disease in the first place and treat progression of diabetic renal disease to kidney failure, the mechanisms that lead from high blood glucose levels to damage of the vascular bed of the glomerulus and to end stage renal...